Publicação: Age-related expression of TGF beta family receptors in human cumulus oophorus cells
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Springer
Resumo
During ovarian follicle growth, local cellular interactions are essential for oocyte quality acquisition and successful fertilization. While cumulus cells (CCs) nurture oocytes, they also deliver oocyte-secreted factors (OSFs) that activate receptors on CCs. We hypothesized that disturbance of those interactions contributes to age-related lower reproductive success in women submitted to assisted reproductive technology treatments.
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Adult, Anaplastic Lymphoma Kinase, Bone Morphogenetic Protein Receptors, Type I, Bone Morphogenetic Protein Receptors, Type II, Cumulus Cells, Female, Fertilization in Vitro, Gene Expression Regulation, Developmental, Humans, Middle Aged, Oocytes, Ovarian Follicle, Protein-Serine-Threonine Kinases, Receptor Protein-Tyrosine Kinases, Receptor, Transforming Growth Factor-beta Type I, Receptors, Transforming Growth Factor beta, Reproductive Techniques, Assisted, Portugal
Citação
Ribeiro, A., Freitas, C., Matos, L. et al. Age-related expression f TGF beta family receptors in human cumulus oophorus cells. J Assist Reprod Genet 34, 1121–1129 (2017).