Publicação: Main Determinants of PON1 Activity in Hemodialysis Patients
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Karger
Resumo
Cardiovascular diseases are the major cause of morbidity and mortality in hemodialysis (HD) patients. These patients present reduced paraoxonase 1 (PON1) activity that depends on genetic and non-genetic factors; however, how these factors influence PON1 activity in HD patients is poorly clarified. Our aim was to evaluate the influence of two polymorphisms and non-genetic factors on PON1 activity in HD patients.
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Palavras-chave
Adiponectin, Aged, Aged, 80 and over, Anemia, Aryldialkylphosphatase, Biomarkers, C-Reactive Protein, Enzyme Activation, Erythropoietin, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Inflammation, Interleukin-6, Kidney Failure, Chronic, Lipids, Male, Middle Aged, Polymorphism, Genetic, Prognosis, Risk Factors, Renal Dialysis, Madeira Island, Portugal
Citação
Am J Nephrol 2012;36:317–323