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Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells
(ASBMB, 2013-11-01) Nunes, Raquel J.; Oliveira, Paula de; Lages, Ana; Becker, Jörg D.; Marcelino, Paulo; Barroso, Eduardo; Perdigoto, Rui; Kelly, Jeffery W.; Quintas, Alexandre; Santos, Susana C. R.
"Background: The biological effects of transthyretin proteins on vasculature remain unknown.
Results: V30M transthyretin tetramer modulates endothelial global gene expression, down-regulating pro-angiogenic genes,
inducing apoptosis and inhibiting migration.
Conclusion: Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells.
Significance: This work has critical implications in the prevention of early hepatic artery thrombosis in familial amyloidotic polyneuropathy patients after liver transplantation."